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High-Yield Differentiators
Every NBME stem is built around a pivot - the single detail that separates the right answer from the closest distractor. These are the pairs and triplets that come up over and over again, with the pivot that decides each one.
Featured
ITP vs TTP vs HUS vs DIC →Four thrombocytopenias. The pivot is coags + schistocytes + kidneys, in that order.
Browse the full library on the Bit Library. Complete list below:
Heme/Onc
- ITP vs TTP vs HUS vs DIC
- Hemophilia A vs B vs vWD
- Iron deficiency vs ACD vs Thalassemia
- AML vs ALL vs CML vs CLL
- Hodgkin vs Non-Hodgkin lymphoma
- Anemia - Microcytic / Normocytic / Macrocytic
- Intrinsic hemolytic anemias
- MPNs - PV, ET, PMF, CML
Renal
- Bartter vs Gitelman vs Liddle
- Nephritic vs Nephrotic syndromes
- RTA Type 1 vs 2 vs 4
- AKI - Prerenal vs Intrinsic vs Postrenal
Endo
- DKA vs HHS
- Conn vs Cushing vs Pheo
- Sheehan vs Simmonds vs Empty Sella
- Hashimoto vs Graves vs De Quervain
- Type 1 vs Type 2 Diabetes
- Hyper- vs Hypoparathyroidism
- MEN 1 vs 2A vs 2B
Cardio
- AS vs HOCM (murmur manoeuvres)
- Restrictive vs Constrictive CMP
- Heart Failure - HFrEF vs HFpEF
- Cardiac Murmurs by Location & Timing
- ACS - STEMI vs NSTEMI vs UA
Neuro
- UMN vs LMN signs
- Wernicke vs Korsakoff
- MS vs NMO vs ADEM
- Stroke Syndromes by Vessel
- Dementia - AD / Vascular / FTD / DLB / NPH
- Parkinson / Essential tremor / Huntington / Wilson
Rheum / Immuno
- GPA vs Goodpasture vs EGPA
- SLE vs Drug-induced lupus vs MCTD
- Hypersensitivity Types I-IV
- DiGeorge / Bruton / CVID / Hyper-IgM / SCID
- CGD / Chédiak / Job / LAD
Genetics
Biochem
- PKU / MSUD / Homocystinuria / Alkaptonuria
- Marfan vs Homocystinuria vs EDS
- Glycogen Storage Diseases
- Lysosomal Storage Diseases
- Vitamin Deficiencies
Pathology
Micro
- Hepatitis A vs B vs C vs D vs E
- Herpesviruses
- Salmonella vs Shigella
- Endotoxin vs Exotoxin
- Exotoxin Syndromes
- HIV stages + opportunistic infections
- Tuberculosis - Primary / Latent / Secondary / Miliary
- Dimorphic Fungi
- Plasmodium species
Pharm / Tox
- Anion gap MUDPILES
- Non-anion-gap HARDUP
- Antibiotic Mechanism Classes
- Antiarrhythmics - Vaughan-Williams
- Diuretics by Nephron Site
Behavioral
- Defense Mechanisms
- Personality Disorders - Clusters A/B/C
- Mood Disorders - MDD / Dysthymia / Bipolar I & II
GI
OB / Gyn
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Going deeper on a system?
Each pair above has a full subject PDF behind it. The 14-PDF subject bundle walks through the mechanism, the trap-block drills, and the high-yield practice for every system. Optional - these differentiators alone will move your score.